Synthesis and biological evaluation of the progenitor of a new class of cephalosporin analogues, with a particular focus on structure-based computational analysis.
We present the synthesis and biological evaluation of the prototype of a new class of cephalosporins, containing an additional isolated beta lactam ring with two phenyl substituents.This new compound is effective against Gram positive microorganisms, with a potency similar to 8n joico lumishine that of ceftriaxone, a cephalosporin widely used in cl